plink Error: File read failure.

1、问题，莫名其妙出现下面的问题，折腾半天也没有找出原因，后来索性暴力解决，直接解压文件看看咋回事， 解压半天提示文件损坏，。。。。

Error: File read failure.   

 

 

 

2、重新下载文件，测试

root@PC1:/home/GWA_tutorial/2_Population_stratification#plink --vcf ALL.2of4intersection.20100804.genotypes.vcf.gz --make-bed --out ALL.2of4intersection.20100804.genotypes
PLINK v1.90b6.24 64-bit (6 Jun 2021)           www.cog-genomics.org/plink/1.9/
(C) 2005-2021 Shaun Purcell, Christopher Chang   GNU General Public License v3
Logging to ALL.2of4intersection.20100804.genotypes.log.
Options in effect:
  --make-bed
  --out ALL.2of4intersection.20100804.genotypes
  --vcf ALL.2of4intersection.20100804.genotypes.vcf.gz

15974 MB RAM detected; reserving 7987 MB for main workspace.
--vcf: ALL.2of4intersection.20100804.genotypes-temporary.bed +
ALL.2of4intersection.20100804.genotypes-temporary.bim +
ALL.2of4intersection.20100804.genotypes-temporary.fam written.
25488488 variants loaded from .bim file.
629 people (0 males, 0 females, 629 ambiguous) loaded from .fam.
Ambiguous sex IDs written to ALL.2of4intersection.20100804.genotypes.nosex .
Using 1 thread (no multithreaded calculations invoked).
Before main variant filters, 629 founders and 0 nonfounders present.
Calculating allele frequencies... done.
Total genotyping rate is 0.615305.
25488488 variants and 629 people pass filters and QC.
Note: No phenotypes present.
--make-bed to ALL.2of4intersection.20100804.genotypes.bed +
ALL.2of4intersection.20100804.genotypes.bim + ALL.2of4intersection.20100804.genotypes.fam ... done.

这次没有报错。

当plink 处理大文件出现:Error: File read failure错误.  一种可能就是文件损坏！