import pandas as pd df1 = pd.DataFrame({'a':[1,2,3], 'b':[4,5,6]}, columns=['a', 'b']) df2 = pd.DataFrame({'a':[7,8,9], 'b':[6,5,4]}, columns=['a', 'b']) # print(df1) writer = pd.ExcelWriter('a.xls') df1.to_excel(writer, sheet_name='sheet1', index=False) df2.to_excel(writer, sheet_name='sheet2', index=False) writer.save()